KEMS9612 CH3: Target Oriented Synthesis TOS (JSS31) (2 cr)

Study level:
Advanced studies
Grading scale:
Pass - fail
Language:
English
Responsible organisation:
Faculty of Mathematics and Science
Curriculum periods:
2022-2023, 2023-2024

Description

The course focuses on how to design efficient synthetic routes to organic target molecules with special focus on bioactive compounds (natural products and pharmaceuticals). The course will cover the following main topics: (1) Principles of synthesis design, retrosynthesis and target molecule analysis, (2) Canonical synthetic strategies (transform-based, structure-goal, topological, stereochemical, functional-group based, non-canonical strategies), (3) Divergent and convergent strategies, (4) Symmetry and hidden symmetry, (5) Analysis and comparison of synthetic routes, (6) Implementation of a strategy to design a practical synthesis, (7) Industrial considerations for target oriented synthesis, (8) AI tools in synthesis design.

Learning outcomes

After the course a student will be able to design, compare and evaluate alternative synthetic routes to target molecules, use chemical databases to help with the synthesis design process, and be able to collaboratively design syntheses. The student will also be able to recognize main challenges in synthesizing target molecules in the industrial field.

Description of prerequisites

B.Sc. or equivalent in chemistry.

Completion methods

Method 1

Description:
Mandatory class, workshop and problem set attendance, as well as completion of the take-home final examination.
Evaluation criteria:
The course will be graded either pass or fail. In order to pass the course at least 50% of the total points must be achieved.
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Parts of the completion methods
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Participation in teaching (2 cr)

Type:
Participation in teaching
Grading scale:
Pass - fail
Evaluation criteria:
The course will be graded either pass or fail. In order to pass the course at least 50% of the total points must be achieved.
Language:
English
Study methods:

Mandatory class, workshop and problem set attendance, as well as completion of the take-home final examination. 

No published teaching