BENS7011 BIO1: MicroRNA Biology and Function (JSS35) (1 cr)

This course develops a comprehensive understanding of microRNA biology, with a focus on their molecular mechanisms, functional diversity, and translational applications. Students will explore how microRNAs and their isomiR variants regulate gene expression, participate example in ageing processes, and serve as robust biomarkers in cancer. Through case studies such as the EV-miRNA field and the commercial success story of TAmiRNA, the course also illustrates how basic research can evolve into clinically relevant innovations. In addition, students will gain practical insight into the analysis of miRNA and isomiR data, preparing them to critically evaluate and apply small RNA research in various biological contexts.    

After completing this course, the student:

· Understands the core principles of microRNA biology and the mechanisms regulating miRNA function.

· Recognizes different carriers and transport mechanisms of microRNAs, including extracellular vesicles.

· Understands isomiR expression, its biological relevance, and the fundamentals of isomiR expression data analysis.

· Is able to connect microRNA biology to diverse biological processes such as ageing and cancer development.

· Can describe how microRNAs function as biomarkers in health and disease and evaluate their translational potential.

Basic courses in biochemistry and molecular biology.