KEMS5450 Reaction Mechanisms and Catalysis (4 cr)

Determination of reaction mechanisms: isolation of intermediates, crossover-experiments; kinetic methods, especially primary, secondary and reverse kinetic isotope effects, substituent effects, linear free energy (Hammett) relationships, solvation effects. Homogenous catalysis: specific and general acid-base catalysis, Marcus theory, solvent effects, hydrogen bond catalysis, catalysis in water, enzymes and small molecules as catalysts, asymmetric catalysis, transition metal catalysis.

The course will deepen the understanding of concepts of physical chemistry that forms the basis of reactivity in synthetic chemistry. Special emphasis is placed on modern methods used for the determination of reaction mechanisms. During the course, the students will also be provided opportunities to practice problem solving in group sessions.

Key skills learned. After the course, the student

• Manages the planning of work, tasks, and time use and adheres to agreed schedules.
• Can combine and apply the learned in the course in different contexts.
• Can independently search the chemical literature related to the topics of the course, and produce an understandable and professional written presentation as well as oral presentations.
• Is able to provide answers to the given tasks and problems orally and in writing and can clearly explain their answer or opinion when working in the group.
• Understands ethical and environmental issues related to the subject of the course and is able to consider their implications and solutions.
• Can consider the effects of chemistry and humanity as kinetic problems, where the rate of waste production exceeds its rate of degradation or recovery.

The course is lectured in academic years 2024-2025 and 2026-2027. 

KEMS541 Advanced Course in Organic Course or a very good command of B.Sc. level chemistry and organic chemistry or organometallic chemistry is required. The course is intended for advanced undergraduate or even 1st year graduate students.

• Anslyn & Dougherty: Modern Physical Organic Chemistry (University Science Books 2006, ISBN: 978-1-891389-31-3)