KEMA283 Organic Chemistry 2 (4 cr)
Introduction to carbonyl chemistry. Nucleophilic addition reactions to the carbonyl group. Reduction of carbonyl compounds. Organometallic reagents in carbonyl additions. Carboxylic acid derivatives - reactions via nucleophilic substition. Enolate chemistry: substitution reactions in the α carbon of carbonyl compounds. Carbonyl condensation reactions (Claisen and related condensations). Applications in industrial chemistry and biochemistry, including enzymatic reactions involving carbonyl groups in cellular metabolism.
Exercises, problem sets, and final exam.
The course can also be completed by only taking the exam.
Problem sets, e-problems and the exam will be graded and the grade will be based on the total score acquired. Alternatively, the grade can be based on an exam alone.
The problems and the exam will evaluate the students' ability to understand functional group reactivity, different reaction methods, mechanistic thinking, and reaction mechanisms.
A passing grade (1/5) requires 50% of the overall score. Higher grades require higher scores; a linear grading will be used, with a grade 5/5 requiring 90% of the overall score.
The course will take place during Period 4 (Spring).
- Janice Smith: Organic Chemistry (5th Ed.), McGraw-Hill 2016; ISBN: 9780077189013