NANS7004 Methods for the Characterization of Supramolecular Complexes (JSS29) (2 cr)

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Study level:

Advanced studies

Grading scale:

Pass - fail

Language:

English

Responsible organisation:

Faculty of Mathematics and Science

Curriculum periods:

2017-2018, 2018-2019, 2019-2020

Description

Content

Practical aspects for characterization of intermolecular interactions in supramolecular complexes using spectroscopic techniques and isothermal titration calorimetry. The topics include geometrical characterization of complex structures (mainly NMR experiements), thermodynamic characterization (spectroscopic titrations and isothermal titration calorimetry), and kinetic characterizarion (fast and slow exchange binding processes on the NMR timescales, EXSY, complete bandshape analysis). During practical sessions example data is processed and analysed using freely available software, therefore, bringing your own laptop is recommended. Participants are invited to bring their own samples or data for measurement and analysis during practical sessions (optional).

Completion methods

Lectures and practical sessions, and assigned homework (80 %).

Learning outcomes

The student will learn basic concepts of supramolecular binding and the structural characterization of supramolecular complexes in solution. The student will understand what kind of information can be extracted from NMR and optical spectroscopy titrations, as well as isothermal titration calorimetry (ITC) experiments. The student will learn to select the appropriate range of concentrations to perform titration experiments based on the expected magnitude of the binding constants to be determined. The student will be acquainted with basic NMR experiments addressed to the kinetic characterization of supramolecular systems. The student will be familiarized with methods for the treatment and analysis of titration data, as well as those produced by the kinetic characterization experiments.

Description of prerequisites

The student knows basic concepts of supramolecular chemistry, different types of weak intermolecular interactions, and basic operating principles of NMR and optical spectroscopy.

Completion methods

Method 1

Select all marked parts

Parts of the completion methods

Unpublished assessment item